Anal canal adenocarcinoma locally treated with abdominoperineal resection after chemoradiotherapy: case report and review of literature

Multimodal treatment in anal canal adenocarcinoma

  • Andreia Amado Centro Hospitalar Vila Nova de Gaia/Espinho, Porto, Portugal
  • Tatiana Queirós Centro Hospitalar Vila Nova de Gaia/Espinho, Porto, Portugal
  • Sílvia Dantas Costa Centro Hospitalar Vila Nova de Gaia/Espinho, Porto, Portugal
  • Amélia Tavares Centro Hospitalar Vila Nova de Gaia/Espinho, Porto, Portugal
  • Lurdes Gandra Centro Hospitalar Vila Nova de Gaia/Espinho, Porto, Portugal
Keywords: adenocarcinoma; anal; abdominoperineal resection; chemoradiotherapy

Abstract

Background: Primary adenocarcinoma of the anal canal is rare, representing less than 20% of anal canal cancers. Given the limited data regarding treatment and outcomes, the management of this type of cancer is focused on a combined modality therapy involving radical surgery and neoadjuvant/adjuvant chemoradiotherapy.

Case study: A 74-year-old woman presented with pruritus and anal pain with 6 months duration. MRI showed a semi-concentric mass in anal canal posterior wall. After an incisional biopsy that revealed an adenocarcinoma, the patient underwent neoadjuvant chemoradiotherapy followed by laparoscopic abdominoperineal resection.

Conclusion: There is limited research into anal adenocarcinoma since the rarity of this condition. The prognosis of anal adenocarcinoma is poor and the management remains controversial. Therapy strategies are not well established, however, general agreement states that a combined multimodality (combination of radical surgical resection and pre or postoperative chemoradiotherapy) achieves the best outcome.

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Published
2021-09-28
How to Cite
1.
Amado A, Tatiana Queirós, Sílvia Dantas Costa, Amélia Tavares, Lurdes Gandra. Anal canal adenocarcinoma locally treated with abdominoperineal resection after chemoradiotherapy: case report and review of literature. Acta Chir. Croat. [Internet]. 2021Sep.28 [cited 2021Oct.17];18(1):7-10. Available from: https://acc.hkd.com.hr/index.php/ACC/article/view/130
Section
Case Reports