ALPPS - new approach in the treatment of advanced liver tumors
ALPPS (Associated Liver Partition and Portal Vein Ligation for Staged Hepatectomy) is an innovative surgical procedure which was presented for the first time in 2012, and in last two years it has become widely accepted by hepatobiliary surgeons and cosequently three ALPPS procedures have been performed at our institution so far. Considering that ALPPS is a relatively new method, indicated only in carefully selected patients, we still expect studies on larger number of patients, but according to last results ALPPS has proved to be a very successful surgical method which allows resectability of tumors that were considered irresectable, by promoting surprisingly fast and intensive hypertrophy of future liver remnant.
Schnitzbauer A, Lang S A, Fichtner-Feigl, et al. In situ split with portal vein ligation induces rapid left lateral lobe hypertrophy enabling two-staged extended right hepatic resection. Berlin: Oral Presentation; 2010. p. 35.
Bertens KA, Hawel J, Lung K, Buac S, Pineda-Solis K, Hernandez-Alejandro R. ALPPS: challenging the concept of unresectability – a systematic review. Int J Surg 2015 Jan;13: 280–287.
Alvarez FA, Ardiles V, de Santibanes M, Pekolj J, de Santibanes E. Associating liver partition and portal vein ligation for staged hepatectomy offers high oncological feasibility with adequate patient safety: a prospective study at a single center. Ann Surg 2015 Apr;261(4): 723–732.
Torres OJ, Moraes-Junior JM, Lima e Lima NC, Moraes AM. Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS): a new approach in liver resections. Arquivos brasileiros de cirurgia digestiva: ABCD. Brazilian archives of digestive surgery 2012;25(4): 290–2. Epub 2013/02/16.
Tschuor C, Croome KP, Sergeant G, et al. Salvage parenchymal liver transection for patients with insufficient volume increase after portal vein occlusion – an extension of the ALPPS approach. European journal of surgical oncology: the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2013;39(11): 1230–1235.
Vyas SJ, Davies N, Grant L, et al. Failure of portal venous embolization. ALPPS as salvage enabling successful resection of bilobar liver metastases. J Gastrointest Cancer 2014.
Hernandez-Alejandro R, Bertens KA, Pineda-Solis K, Croome KP. Can we improve the morbidity http://www.kbc-zagreb.hr/and mortality associated with the associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) procedure in the management of colorectal liver metastases? Surgery. 2014. Epub 2014/10/06.
Nadalin S, Capobianco I, Li J, Girotti P, Königsrainer I, Königsrainer A. Indications and limits for associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) lessons learned from 15 cases at a single centre. Z Gastroenterol 2014;52(1): 35–42.
Schadde E, Ardiles V, Slankamenac K, et al. ALPPS offers a better chance of complete resection in patients with primarily unresectable liver tumors compared with conventional-staged hepatectomies: Results of a multicenter analysis. World J Surg. 2014;38(6): 1510–1519.
Schadde E, Ardiles V, Robles-Campos R, et al. Early Survival and Safety of ALPPS: First Report of the International ALPPS Registry. Ann Surg 2014;260(5): 829–838.
Herman P, Krüger JAP, Perini MV, Coelho FF, Cecconello I. High Mortality Rates After ALPPS: the devil is the indication. J Gastrointest Cancer 2015.
Copyright (c) 2016 Acta Chirurgica Croatica
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The authors hereby authorize the Acta Chirurgica Croatica (ACC) to publish their work.
The authors are aware that although ACC is Open Access journal, the copyright of all material published is vested in ACC. Open access articles are freely available to read, download, and share from the time of publication under the terms of the Creative Commons License Attribution ‐ NonCommerical No Derivative (CC BY‐NC‐ND) license. This license does not permit reuse for any commercial purposes nor does it cover the reuse or modification of individual elements of the work (such as figures, tables, etc.) in the creation of derivative works without specific permission of ACC and appropriate acknowledgment of its source. The authors permit ACC to allow third parties to copy any part of the work without asking for permission, provided that the reference to the source is given and that this is not done for commercial purposes. Except for copyright, other proprietary rights related to the work (e.g., patent or other rights to any process or procedure) shall be retained by the author. To reproduce any text, figures, tables, or illustrations from this work in future works of their own, the author must obtain written permission from ACC.
Each of the author(s) hereby also grants permission to ACC to use such author’s name and likeness in connection with any past, present or future promotional activity by ACC, including, but not limited to, promotions for upcoming issues or publications, circulation solicitations, advertising or other publications in connection with ACC. Also, each of the author(s) hereby grants permission to ACC to use the manuscript in editorial research related to the improvement of editorial conduct, decision making, and issues related to peer review.
Each of the author(s) hereby releases and shall indemnify and hold harmless ACC and its successors, assigns, licensees, officers, directors, employees, and their respective heirs and representatives from and against any and all liabilities, losses, damages and expenses arising out of any claims of any kind that may be asserted against any of them based in whole or in part on any breach of the author(s)’ representations or warranties herein or in the work or anything contained in the work, including but not limited to any claims for copyright infringement or violation of any rights of privacy or publicity.