Tachosil® in hepatobiliary surgery - our experience

  • Mate Skegro
  • Ognjan Deban
  • Goran Pavlek
Keywords: TachoSil®, haemostasis, bleeding time, liver resection

Abstract

TachoSil® is a product used in surgical branches of medicine as a supportive therapy. Specifically, this product is used for local support of haemostasis and tissue sealing during surgical treatment where satisfactory results have not been achieved by conventional techniques. We observed the duration of intraoperative hemostasis, compared it with already available results showing the duration of haemostasis in other cases and clearly demonstrated the benefits of TachoSil®. In a sample of ten patients with intraoperative use of TachoSil®, the mean value of haemostasis was 4.2 min (3.2 min-7 min). A leakage of bile into the abdominal drain was observed in only one patient after the administration of TachoSil®. In hepatobiliary surgery, cost/benefit ratio is undoubtedly in favour of TachoSil®. Our results correlate well with those of our colleagues from around the world.

Downloads

Download data is not yet available.

References

TachoSilR product monograph, Denmark, September 2011.

Škegro M, Romić B, Gojević A, Baotić T, Deban O, Petrović I: Kirurško liječenje jetrenih metastaza; 7. kongres Hrvatskog društva za digestivu kirurgiju - usmeno priopćenje.

Sierra DH. Fibrin sealant adhesive systems: a review of their chemistry, material properties and clinical applications. J Biomater Appl 1993;7:309-52.

Bloom AL. Physiology of blood coagulation. Haemostasis 1990;20:14-29.

Erdogan D, de Graaf W, van Gulik TM. Adhesive strength of fibrinogencoated collagen patch or liquid fivrin sealant in an experimental liver resection model in pigs. Eur Surg Res 2008;41:298-302.

Nycomed Clinical Trial Report. Trial ID – TC-014-IN. An open, randomised, prospective, multicentre, parallel-group phase III trial to compare efficacy and safety of TachoCombR S and argon beamer in patients undergoing liver resection. 2002.

Nycomed Clinical Trial Report. Trial ID – TC-016-IN. An open, randomised, prospective, multicentre, parallel-group trial to compare efficacy and safety of TachoCombR S versus argon beam coagulator treatment in subjects undergoing liver resection (II). 2003.

Broelsch CE, Fruhaus NR, de Hemptinne B, et al. TachoSilR as haemostatic treatment in hepatic surgery. HPB 2005;7:28.

Frilling A, Stavrou G, Mischinger HJ, et al. Effectiveness of a new carrierbound fibrin sealant versus argon beamer as hemostatic agent during liver resection: a randomized prospective trial. Langenbeck’s Arch Surg 2005;390:114-20.

Briceno J, Naranjo A, Ciria R, et al. A prospective study of the efficacy of clinical application of a new carrier-bound fibrin sealant after liver resection Arch Surg 2010;145:482-8.

Toti L, Attia M, Manzia TM, et al. Reduction in bile leaks following adult split liver transplant using a fibrin-collagen sponge: A pilot study. Dig Liver Dis. 2010;42:205-9.

Pozzo G, Amerio G, Bona R, et al. A new method of jejunal reconstruction after pancreaticoduodenectomy. Hepatogastroenterology 2010;57:1305-8.

Chirletti P, Caronna R, Fanello G, et al. Pancreaticojejunostomy with application of fibrinogen/thrombin-coated collagen patch (TachoSilR) in Roux-en-Y reconstruction after pancreaticoduodenectomy. J Gastrointest Surg 2009;13:1396-8.

Fischer L, Seiler CM, Broelsch CE, et al. Hemostatic efficacy of TachoSilR in liver resection compared with argon beam coagulator treatment: an open, randomized, prospective, multicenter, parallel-group trial. Surgery 2011;149:48-55.

Lang G, Csekeo A, Stamatis G, et al. Efficacy and safety of topical application of human fibrinogen/thrombin-coated collagen patch (TachoCombR) for treatment of air leakage after standard lobectomy. Eur J Cardiothorac Surg 2004;25:160-6.

Nycomed Clinical Trial Report. Trial ID – TC-013-IN. An open, randomised, prospective, multicentre, parallel-group phase III trial to compare efficacy and safety of TachoCombR S versus standard surgical treatment in patients undergoing lung lobectomy for lung cancer and requiring treatment for air leakage after primary stapling. 2004.

Eloy R. Comparative hemostatic wound sealing effect and resistance of absorbable TachoCombR H and TachoCombR S – Experimental study in the pig model of acute pancreatitis. Study No. 73E801. Nycomed Research Report No. 5127. 1998.

Rolle U, Schneider A, Weib J, et al. Histological findings of TachoCombR applied on serosal defects in a rabbit model. 5th World Congress on Trauma, Shock, Inflammation and Sepsis, 26 February - 4 March 2000, Munich, Germany.

Schelling G, Block T, Blanke E, et al. The effectiveness of a fibrinogenthrombin-collagen-based hemostatic agent in an experimental arterial bleeding model. Ann Surg 1987;205:432-5.

Schelling G, Block T, Gokel M, et al. Application of a fibrinogenthrombincollagen-based hemostyptic agent in experimental injuries of liver and spleen. J Trauma 1988;28:472-5.

Martis G, Miko I, Szendroi T, et al. Results with collagen fleece coated with fibrin glue (TachoCombR). A macroscopical and histological experimental study. Acta Chir Hung 1997;36:221-2.

Published
2012-03-15
How to Cite
1.
Skegro M, Deban O, Pavlek G. Tachosil® in hepatobiliary surgery - our experience. Acta Chir. Croat. [Internet]. 2012Mar.15 [cited 2020Dec.5];9(1):35-8. Available from: https://acc.hkd.com.hr/index.php/ACC/article/view/78
Section
Articles

Most read articles by the same author(s)